The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Doxorubicin is an effective anti-tumor agent with a cumulative dose-dependent
cardiotoxicity. In addition to its principal toxic mechanisms involving iron and redox …

Silymarin extracted from milk thistle consisting of flavonolignan silybin has shown
chemopreventive and chemosensitizing activity against various cancers. The present review …

Cardiovascular diseases (CVDs) remain the leading cause of death in the developed
countries. Taking into account the mounting evidence about the role of cytochrome P450 …

Arachidonic acid is metabolized by enzymes of the CYP4A and 4F families to 20-
hydroxyeicosatetraeonic acid (20-HETE), which plays an important role in the regulation of …

HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …

Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …

Enzymes in the cytochrome P450 4 (CYP4) family are involved in the metabolism of fatty
acids, xenobiotics, therapeutic drugs, and signaling molecules, including eicosanoids …

Significance: Despite their serious side effects, anthracyclines (ANTs) are the most
prescribed chemotherapeutic drugs because of their strong efficacy in both solid and …

To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of
systems pharmacology will be integrated using structured ontological approaches, analytics …