[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping
MC Campbell, SA Tishkoff - Annu. Rev. Genomics Hum. Genet., 2008 - annualreviews.org
Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …
important for reconstructing human evolutionary history and for understanding the genetic …
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …
Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance
Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …
liver. Expression is highly variable both between individuals and within individuals, owing to …
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
H Wang, LM Tompkins - Current drug metabolism, 2008 - ingentaconnect.com
Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …
Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance
Polymorphisms in drug-metabolizing enzymes and drug transporters contribute to wide and
inheritable variability in drug pharmacokinetics, response and toxicity. One of the less well …
inheritable variability in drug pharmacokinetics, response and toxicity. One of the less well …
[HTML][HTML] Insights into CYP2B6-mediated drug–drug interactions
Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug
metabolism than was previously believed. The discovery of multiple important substrates of …
metabolism than was previously believed. The discovery of multiple important substrates of …
Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients
C Wyen, H Hendra, M Vogel, C Hoffmann… - Journal of …, 2008 - academic.oup.com
Objectives The aim of this study was to investigate the frequency of CYP2B6 polymorphisms
(according to ethnicity) and the influence of heterozygosity and homozygosity on plasma …
(according to ethnicity) and the influence of heterozygosity and homozygosity on plasma …
The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition
Significant intra-and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …
Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs
Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …