Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications

J Iredell, J Brown, K Tagg - Bmj, 2016 - bmj.com
Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is
increasingly dominated by the mobilization of continuously expressed single genes that …

The emerging threat of multidrug-resistant Gram-negative bacteria in urology

HM Zowawi, PNA Harris, MJ Roberts… - Nature Reviews …, 2015 - nature.com
Antibiotic resistance in Gram-negative uropathogens is a major global concern. Worldwide,
the prevalence of Enterobacteriaceae that produce extended-spectrum β-lactamase or …

An update on the management of urinary tract infections in the era of antimicrobial resistance

MS Bader, M Loeb, AA Brooks - Postgraduate medicine, 2017 - Taylor & Francis
Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a
growing concern due to limited therapeutic options. Gram-negative bacteria, specifically …

Carbapenem therapy is associated with improved survival compared with piperacillin-tazobactam for patients with extended-spectrum β-lactamase bacteremia

PD Tamma, JH Han, C Rock, AD Harris… - Clinical Infectious …, 2015 - academic.oup.com
Background. The effectiveness of piperacillin-tazobactam (PTZ) for the treatment of
extended-spectrum β-lactamase (ESBL) bacteremia is controversial. We compared 14-day …

A review of ten years of the study for monitoring antimicrobial resistance trends (SMART) from 2002 to 2011

I Morrissey, M Hackel, R Badal, S Bouchillon… - Pharmaceuticals, 2013 - mdpi.com
Surveillance of antimicrobial agent resistance provides important information to guide
microbiologists and infectious disease specialists understanding of the control and the …

β-lactam and β-lactamase inhibitor combinations in the treatment of extended-spectrum β-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of …

PNA Harris, PA Tambyah, DL Paterson - The Lancet Infectious …, 2015 - thelancet.com
The spread of extended-spectrum β-lactamase (ESBL) genes in Enterobacteriaceae such as
Escherichia coli or Klebsiella spp is a major challenge to modern medical practice …

In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

K Young, RE Painter, SL Raghoobar, NN Hairston… - BMC microbiology, 2019 - Springer
Background The prevalence of antibiotic resistance is increasing, and multidrug-resistant
Pseudomonas aeruginosa has been identified as a serious threat to human health. The …

Susceptibility patterns and ESBL rates of Escherichia coli from urinary tract infections in Canada and the United States, SMART 2010–2014

SH Lob, LE Nicolle, DJ Hoban, KM Kazmierczak… - … and infectious disease, 2016 - Elsevier
Increasing antimicrobial resistance in urinary tract infections (UTI) is a concern. To evaluate
resistance trends, 3498 Escherichia coli UTI isolates were collected from 2010 to 2014 in the …

Treatment of multidrug-resistant Gram-negative infections in children

AJ Hsu, PD Tamma - Clinical infectious diseases, 2014 - academic.oup.com
Antibiotic resistance in conjunction with the erosion of the drug development pipeline may
lead us into a bleak future, a “post-antibiotic era.” Because of a shortage of studies …

Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae …

AJ Denisuik, PRS Lagacé-Wiens… - Journal of …, 2013 - academic.oup.com
Objectives To assess the proportion of Escherichia coli and Klebsiella pneumoniae from
Canadian hospitals that produce extended-spectrum β-lactamases (ESBLs), AmpC β …