Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Metabolomics in cancer biomarker discovery: current trends and future perspectives

EG Armitage, C Barbas - Journal of pharmaceutical and biomedical …, 2014 - Elsevier
Cancer is one of the most devastating human diseases that causes a vast number of
mortalities worldwide each year. Cancer research is one of the largest fields in the life …

A community-driven global reconstruction of human metabolism

I Thiele, N Swainston, RMT Fleming, A Hoppe… - Nature …, 2013 - nature.com
Multiple models of human metabolism have been reconstructed, but each represents only a
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus' …

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

WB Dunn, D Broadhurst, P Begley, E Zelena… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

Statistical strategies for avoiding false discoveries in metabolomics and related experiments

DI Broadhurst, DB Kell - Metabolomics, 2006 - Springer
Many metabolomics, and other high-content or high-throughput, experiments are set up
such that the primary aim is the discovery of biomarker metabolites that can discriminate …

Computational and statistical analysis of metabolomics data

S Ren, AA Hinzman, EL Kang, RD Szczesniak, LJ Lu - Metabolomics, 2015 - Springer
Metabolomics is the comprehensive study of small molecule metabolites in biological
systems. By assaying and analyzing thousands of metabolites in biological samples, it …

[HTML][HTML] Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative …

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Metabolomics: current technologies and future trends

K Hollywood, DR Brison, R Goodacre - Proteomics, 2006 - Wiley Online Library
The ability to sequence whole genomes has taught us that our knowledge with respect to
gene function is rather limited with typically 30–40% of open reading frames having no …

Phytochemical Profiling of Leaf, Stem, and Tuber Parts of Solena amplexicaulis (Lam.) Gandhi Using GC‐MS

K Krishnamoorthy… - … scholarly research notices, 2014 - Wiley Online Library
Objective. To explore the possible bioactive compounds in the methanolic extracts of leaf,
stem, and tuber parts of the medicinal climber, Solena amplexicaulis, using GC‐MS …

[HTML][HTML] Connecting extracellular metabolomic measurements to intracellular flux states in yeast

ML Mo, BØ Palsson, MJ Herrgård - BMC systems biology, 2009 - Springer
Background Metabolomics has emerged as a powerful tool in the quantitative identification
of physiological and disease-induced biological states. Extracellular metabolome or …