Role of natural products for the treatment of Alzheimer's disease

T Noori, AR Dehpour, A Sureda… - European journal of …, 2021 - Elsevier
Negative psychological and physiological consequences of neurodegenerative disorders
represent a high social and health cost. Among the neurodegenerative disorders …

Metal–Organic Frameworks as Sensors for Human Amyloid Diseases

JP Leite, F Figueira, RF Mendes, FA Almeida Paz… - ACS …, 2023 - ACS Publications
Metal–organic frameworks (MOFs) are versatile compounds with emergent applications in
the fabrication of biosensors for amyloid diseases. They hold great potential in biospecimen …

Metal-organic frameworks: A promising option for the diagnosis and treatment of Alzheimer's disease

S Tajahmadi, H Molavi, F Ahmadijokani… - Journal of Controlled …, 2023 - Elsevier
Beta-amyloid (Aβ) peptide is one of the main characteristic biomarkers of Alzheimer's
disease (AD). Previous clinical investigations have proposed that unusual concentrations of …

High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation

W Peng, Z Zhu, J Lou, K Chen, Y Wu, C Chang - eLight, 2023 - Springer
The accumulation and deposition of amyloid can cause a variety of neurodegenerative
diseases, including Alzheimer's and Parkinson's disease. The degradation or clearance of …

Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease

M Zhao, XF Jiang, HQ Zhang, JH Sun, H Pei… - Ageing research …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder
characterized by senile plaques and neurofibrillary tangles, is the most common form of …

Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review

Z Haghighijoo, L Zamani, F Moosavi… - European journal of …, 2022 - Elsevier
Quinazolines are considered as a promising class of bioactive heterocyclic compounds with
broad properties. Particularly, the quinazoline scaffold has an impressive role in the design …

Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects

J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …

Flanking regions, amyloid cores, and polymorphism: the potential interplay underlying structural diversity

AA Bhopatkar, R Kayed - Journal of Biological Chemistry, 2023 - ASBMB
The β-sheet–rich amyloid core is the defining feature of protein aggregates associated with
neurodegenerative disorders. Recent investigations have revealed that there exist multiple …

New naphthoquinone thiazole hybrids as carbonic anhydrase and cholinesterase inhibitors: Synthesis, crystal structure, molecular docking, and acid dissociation …

C Efeoglu, O Selcuk, B Demir, E Sahin, H Sari… - Journal of Molecular …, 2024 - Elsevier
Abstract In this study, N-[3-(3-amino-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-4-R-thiazol-2
(3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …

Cobalt induces neurodegenerative damages through impairing autophagic flux by activating hypoxia-inducible factor-1α triggered ROS overproduction

J Tang, Y Li, X Liu, G Yu, F Zheng, Z Guo… - Science of The Total …, 2023 - Elsevier
Cobalt is an environmental toxicant, and excessive bodily exposure can damage the
nervous system. Particularly, our previous study reported that low-dose cobalt (significantly …