The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Global climate change caused by the accumulation of greenhouse gases (GHGs) has
caused concerns regarding the continued reliance on fossil fuels as our primary energy …

The industrial yeast Pichia pastoris has been harnessed extensively for production of
proteins, and it is attracting attention as a chassis cell factory for production of chemicals …

Natural products account for more than 50% of all small-molecule pharmaceutical agents
currently in clinical use. However, low availability often becomes problematic when a …

Natural products and their derivatives offer a rich source of chemical and biological diversity;
however, traditional engineering of their biosynthetic pathways to improve yields and access …

Producing bio-based chemicals is imperative to establish an eco-friendly circular
bioeconomy. However, the compromised titer of these biochemicals hampers their …

Highlights•Microbial cell factories can be tailored for producing certain 'drop-in'chemicals.•
Metabolic engineering has greatly enhanced the development of microbial cell …

Liquid fuels sourced from fossil sources are the dominant energy form for mobile transport
today. The consumption of fossil fuels is still increasing, resulting in a continued search for …

Highlights•Transporter proteins are essential for substrate uptake, product export, and
intercompartmental metabolite exchange.•Transporter activity of a cell can be engineered to …

Sustainable production of biofuels has provided an attractive alternative to fossil fuels, which
has relieved the concern regarding energy supply and global climate change. Currently …