The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

1 Using functional co‐cultures of rat carotid body (CB) O2 chemoreceptors and
'juxtaposed'petrosal neurones (JPNs), we tested whether ATP and ACh acted as co …

In this review, the maturational changes occurring in the mammalian respiratory network
from fetal to adult ages are analyzed. Most of the data presented were obtained on rodents …

Specialized O 2-sensing cells exhibit a particularly low threshold to regulation by O 2 supply
and function to maintain arterial pO 2 within physiological limits. For example, hypoxic …

Hypoxic chemotransmission in the rat carotid body (CB) is mediated in part by ATP acting on
suramin-sensitive P2X purinoceptors. Here, we use RT-PCR, cloning and sequencing …

Early detection of an O 2 deficit in the bloodstream is essential to initiate corrective changes
in the breathing pattern of mammals. Carotid bodies serve an essential role in this respect; …

Among numerous challenges encountered at the beginning of extrauterine life, the most
celebrated is the first breath that initiates a life-sustaining motor activity 1. The neural …

Key points The retrotrapezoid nucleus (RTN) drives breathing proportionally to brain but its
role during various states of vigilance needs clarification. Under normoxia, RTN lesions …

The ventilatory response to CO2 changes as a function of neonatal development. In rats, a
ventilatory response to CO2 is present in the first 5 days of life, but this ventilatory response …