Interaction of 4′-methylflavonoids with biological membranes, liposomes, and human albumin

A Włoch, P Strugała-Danak, H Pruchnik… - Scientific Reports, 2021 - nature.com
The aim of the study was to compare the impact of three synthesized chemical compounds
from a group of methylated flavonoids, ie 2′-hydroxy-4-methylchalcone (3), 4 …

Chalcone-derived lactones: synthesis, whole-cell biotransformation, and evaluation of their antibacterial and antifungal activity

W Gładkowski, M Siepka, B Żarowska, A Białońska… - Molecules, 2023 - mdpi.com
Four compounds with lactone moiety were synthesized from chalcone 1 in three-or four-step
synthesis. γ-Bromo-δ-lactone 5 was the only product of bromolactonization of acid 4 …

Antiproliferative, antimicrobial and antiviral activity of β-aryl-δ-iodo-γ-lactones, their effect on cellular oxidative stress markers and biological membranes

A Włoch, D Stygar, F Bahri, B Bażanów, P Kuropka… - Biomolecules, 2020 - mdpi.com
The aim of this work was the examination of biological activity of three selected racemic cis-β-
aryl-δ-iodo-γ-lactones. Tested iodolactones differed in the structure of the aromatic fragment …

Chemoenzymatic synthesis of enantiomeric, bicyclic δ-halo-γ-lactones with a cyclohexane ring, their biological activity and interaction with biological membranes

M Mazur, A Włoch, F Bahri, H Pruchnik, A Pawlak… - Biomolecules, 2020 - mdpi.com
Starting from 1-acetyl-1-cyclohexene, three enantiomeric pairs (ee≥ 99%) of bicyclic δ-halo-
γ-lactones with cyclohexane ring were obtained in five-step synthesis. The key …

New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity

A Kamizela, B Gawdzik, M Urbaniak, Ł Lechowicz… - Molecules, 2019 - mdpi.com
This paper presents the synthesis of γ-halo-δ-lactones, δ-iodo-γ-lactones and δ-hydroxy-γ-
lactones from readily available organic substrates such as trans-crotonaldehyde and aryl …

Free and Immobilized Lecitase™ Ultra as the Biocatalyst in the Kinetic Resolution of (E)-4-Arylbut-3-en-2-yl Esters

A Leśniarek, A Chojnacka, R Drozd, M Szymańska… - Molecules, 2020 - mdpi.com
The influence of buffer type, co-solvent type, and acyl chain length was investigated for the
enantioselective hydrolysis of racemic 4-arylbut-3-en-2-yl esters using Lecitase™ Ultra (LU) …

Methoxy-Substituted γ-Oxa-ε-Lactones Derived from Flavanones—Comparison of Their Anti-Tumor Activity In Vitro

A Pawlak, M Henklewska, B Hernández-Suárez… - Molecules, 2021 - mdpi.com
Background: The study investigated four flavanone-derived γ-oxa-ε-lactones: a parent
unsubstituted compound and its three derivatives with the methoxy group in positions 2 …

Enantioselective Transesterification of Allyl Alcohols with (E)-4-Arylbut-3-en-2-ol Motif by Immobilized Lecitase™ Ultra

A Leśniarek, A Chojnacka, R Drozd, M Szymańska… - Catalysts, 2020 - mdpi.com
Lecitase™ Ultra was immobilized on four different supports and tested for the first time as the
biocatalyst in the kinetic resolution of racemic allyl alcohols with the (E)-4-arylbut-3-en-2-ol …

[PDF][PDF] Otrzymywanie i właściwości biologiczne racemicznych i optycznie czynnych laktonów z pierścieniem aromatycznym w pozycji β

W Gładkowski - Wiadomości Chemiczne, 2023 - bibliotekanauki.pl
Natural and synthetic lactones containing an aromatic ring exhibit a number of biological
properties, eg antiproliferative, antifeedant or antimicrobial activity. This review deals with …

Влияние совместного использования гаммаокталактона и хлортетрациклина в рационе бройлеров: живая масса, эффективность использования корма и …

ГК Дускаев, ШГ Рахматуллин, ДБ Косян… - Аграрная наука, 2022 - vetpress.ru
Аннотация Актуальность и методика. Проведена оценка совместного использования
гамма-окталактона и хлортетрациклина в рационе бройлеров на рост, развитие …