Conscious perception in mammals depends on precise circuit connectivity between cerebral
cortex and thalamus; the evolution and development of these structures are closely linked …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

SWI/SNF protein complexes are evolutionarily conserved epigenetic regulators described in
all eukaryotes. In metameric animals, the complexes are involved in all processes occurring …

Summary Chromosome 16p11. 2 reciprocal genomic disorder, resulting from recurrent copy-
number variants (CNVs), involves intellectual disability, autism spectrum disorder (ASD) …

Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-
independently, provide long-term histone replacement in postmitotic cells, including …

Background Congenital hydrocephalus is characterized by ventriculomegaly, defined as a
dilatation of cerebral ventricles, and thought to be due to impaired cerebrospinal fluid (CSF) …

Although chromatin remodelers are among the most important risk genes associated with
neurodevelopmental disorders (NDDs), the roles of these complexes during brain …

Sexual reproduction of Plasmodium falciparum parasites is critical to the spread of malaria
in the human population. The factors that regulate gene expression underlying formation of …

Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe
neurodevelopmental phenotypes with elusive mechanisms in humans. The most common …

Human cerebral organoids (COs) are self-organizing three-dimensional (3D) neural
structures that provide a human-specific platform to study the cellular and molecular …