Molecular photoswitches in aqueous environments

J Volarić, W Szymanski, NA Simeth… - Chemical Society …, 2021 - pubs.rsc.org
Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …

Engineered human blood–brain barrier microfluidic model for vascular permeability analyses

C Hajal, GS Offeddu, Y Shin, S Zhang, O Morozova… - Nature protocols, 2022 - nature.com
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …

Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms

AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …

Understanding cell penetration of cyclic peptides

PG Dougherty, A Sahni, D Pei - Chemical Reviews, 2019 - ACS Publications
Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Membrane active peptides and their biophysical characterization

FG Avci, B Sariyar Akbulut, E Ozkirimli - Biomolecules, 2018 - mdpi.com
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH

WX Wang, TR Douglas, H Zhang… - Nature …, 2024 - nature.com
Structural DNA nanotechnology enables the fabrication of user-defined DNA origami
nanostructures (DNs) for biological applications. However, the role of DN design during …

Antimicrobial peptides and copper (II) ions: Novel therapeutic opportunities

J Portelinha, SS Duay, SI Yu, K Heilemann… - Chemical …, 2021 - ACS Publications
The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …

[HTML][HTML] Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery

M Cárdenas, RA Campbell, MY Arteta… - Current Opinion in …, 2023 - Elsevier
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems,
notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined …

A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas …

N Klubthawee, P Adisakwattana, W Hanpithakpong… - Scientific reports, 2020 - nature.com
Antimicrobial peptides (AMPs) are promising alternatives to classical antibiotics for the
treatment of drug-resistant infections. Due to their versatility and unlimited sequence space …

Design and use of model membranes to study biomolecular interactions using complementary surface-sensitive techniques

LA Clifton, RA Campbell, F Sebastiani… - Advances in Colloid and …, 2020 - Elsevier
Cellular membranes are complex structures and simplified analogues in the form of model
membranes or biomembranes are used as platforms to understand fundamental properties …