This review focuses on the specific biological effects of optically pure silymarin flavo-
nolignans, mainly silybins A and B, isosilybins A and B, silychristins A and B, and their 2, 3 …

The beginning of 1970's may well be regarded as turning point in the area of organic
synthesis when an efficient and straight forward strategy for the reaction of primary and/or …

Hydnocarpin D (HD) is a bioactive flavonolignan compound that possesses promising anti-
tumor activity, although the mechanism is not fully understood. Using T cell acute …

Herein, we report an enantioselective and convergent total synthesis of (+)-pepluanol A, a
structurally intriguing Euphorbia diterpenoid natural product featuring a 5/6/7/3-fused …

A series of neuroprotective hybrid compounds was synthesized by conjugation of the
flavonolignan silibinin with natural phenolic acids, such as ferulic, cinnamic and syringic …

Silybin is a natural compound extensively studied for its hepatoprotective, neuroprotective
and anticancer properties. Envisioning the enhancement of silybin potential by suitable …

α-N-(Fmoc) Amino-γ-lactam dipeptides with a variety of β-substituents were synthesized
stereoselectively with minimal β-elimination by routes employing, respectively, Mitsunobu …

Stereoinvertive deoxyamination involving Bose–Mitsunobu azidation and the Staudinger
reaction, which proceeds under mild conditions in the presence of a neighboring group, was …

An efficient and stereospecific azidation of a cis-disubstituted azepane is described as the
first example of hypervalent silicate-assisted nucleophilic azidation on a substituted seven …

Madecassic acid–isolated from the medicinal herb Centella asiatica–and its derivatives
exhibit cytotoxic activity against the HepG2 liver cancer cell line. Silybin, a natural compound …