MEG3 noncoding RNA: a tumor suppressor
Y Zhou, X Zhang, A Klibanski - Journal of molecular …, 2012 - jme.bioscientifica.com
Maternally expressed gene 3 (MEG3) is an imprinted gene belonging to the imprinted DLK1–
MEG3 locus located at chromosome 14q32. 3 in humans. Its mouse ortholog, Meg3, also …
MEG3 locus located at chromosome 14q32. 3 in humans. Its mouse ortholog, Meg3, also …
Genomic imprinting at the mammalian Dlk1-Dio3 domain
Genomic imprinting causes genes to be expressed or repressed depending on their
parental origin. The majority of imprinted genes identified to date map in clusters and much …
parental origin. The majority of imprinted genes identified to date map in clusters and much …
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
M Stadtfeld, E Apostolou, H Akutsu, A Fukuda, P Follett… - Nature, 2010 - nature.com
Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of
defined sets of transcription factors in somatic cells. It remains controversial whether iPSCs …
defined sets of transcription factors in somatic cells. It remains controversial whether iPSCs …
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as
negative gene regulators. miRNA deregulation is involved in the initiation and progression …
negative gene regulators. miRNA deregulation is involved in the initiation and progression …
Mechanisms regulating imprinted genes in clusters
CA Edwards, AC Ferguson-Smith - Current opinion in cell biology, 2007 - Elsevier
Clustered imprinted genes are regulated by differentially methylated imprinting control
regions (ICRs) that affect gene activity and repression in cis over a large region. Although a …
regions (ICRs) that affect gene activity and repression in cis over a large region. Although a …
Deletions and epimutations affecting the human 14q32. 2 imprinted region in individuals with paternal and maternal upd (14)-like phenotypes
M Kagami, Y Sekita, G Nishimura, M Irie, F Kato… - Nature …, 2008 - nature.com
Abstract Human chromosome 14q32. 2 carries a cluster of imprinted genes including
paternally expressed genes (PEGs) such as DLK1 and RTL1 and maternally expressed …
paternally expressed genes (PEGs) such as DLK1 and RTL1 and maternally expressed …
Epigenetic control of fetal gene expression
TM Nafee, WE Farrell, WD Carroll… - … Journal of Obstetrics …, 2008 - Wiley Online Library
Each differentiated cell type has its own epigenetic signature, which reflects its genotype,
developmental history, and environmental influences, and is ultimately reflected in the …
developmental history, and environmental influences, and is ultimately reflected in the …
Convergent evolution of genomic imprinting in plants and mammals
Parental genomic imprinting is characterized by the expression of a selected panel of genes
from one of the two parental alleles. Recent evidence shows that DNA methylation and …
from one of the two parental alleles. Recent evidence shows that DNA methylation and …
The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers
M Kagami, MJ O'Sullivan, AJ Green, Y Watabe… - PLoS …, 2010 - journals.plos.org
Human chromosome 14q32. 2 harbors the germline-derived primary DLK1-MEG3 intergenic
differentially methylated region (IG-DMR) and the postfertilization-derived secondary MEG3 …
differentially methylated region (IG-DMR) and the postfertilization-derived secondary MEG3 …
The Dlk1-Gtl2 locus preserves LT-HSC function by inhibiting the PI3K-mTOR pathway to restrict mitochondrial metabolism
Summary The mammalian imprinted Dlk1-Gtl2 locus produces multiple non-coding RNAs
(ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the …
(ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the …