As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …

The orbital eccentricities of directly imaged exoplanets and brown dwarf companions
provide clues about their formation and dynamical histories. We combine new high-contrast …

Neutrophils are short-lived blood cells that play a critical role in host defense against
infections. To better comprehend neutrophil functions and their regulation, we provide a …

We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas
(MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We …

Humans and animals can learn to order a list of items without relying on explicit spatial or
temporal cues. To do so, they appear to make use of transitivity, a property of all ordered …

While significant effort has been dedicated to the characterization of epigenetic changes
associated with prenatal differentiation, relatively little is known about the epigenetic …

Background Parkinson's disease (PD) is characterized by the loss of midbrain dopaminergic
neurons (DAn). Previously, we described the presence of DNA hyper-and hypo-methylation …

CHC22 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive
glucose transporter GLUT4 in humans. We performed population genetic and phylogenetic …

Transitive inference (the ability to infer that B> D given that B> C and C> D) is a widespread
characteristic of serial learning, observed in dozens of species. Despite these robust …

Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a
large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration …