Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Influence of the tumor microenvironment on NK cell function in solid tumors

O Melaiu, V Lucarini, L Cifaldi, D Fruci - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

R Romee, M Rosario, MM Berrien-Elliott… - Science translational …, 2016 - science.org
Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute
myeloid leukemia (AML); however, the best approach to maximize NK cell antileukemia …

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

R Romee, S Cooley, MM Berrien-Elliott… - Blood, The Journal …, 2018 - ashpublications.org
New therapies for patients with hematologic malignancies who relapse after allogeneic
hematopoietic cell transplantation (allo-HCT) are needed. Interleukin 15 (IL-15) is a cytokine …

[HTML][HTML] Engineering interferons and interleukins for cancer immunotherapy

PG Holder, SA Lim, CS Huang, P Sharma… - Advanced drug delivery …, 2022 - Elsevier
Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

H Zhu, RH Blum, R Bjordahl… - Blood, The Journal …, 2020 - ashpublications.org
Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer
(NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is …

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming

JA Wagner, M Rosario, R Romee… - The Journal of …, 2017 - Am Soc Clin Investig
NK cells, lymphocytes of the innate immune system, are important for defense against
infectious pathogens and cancer. Classically, the CD56dim NK cell subset is thought to …

Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial

JS Miller, ZB Davis, E Helgeson, C Reilly… - Nature medicine, 2022 - nature.com
There is no cure for HIV infection, and lifelong antiretroviral therapy (ART) is required. N-803
is an IL-15 superagonist comprised of an N72D mutant IL-15 molecule attached to its alpha …

NK cell-based immunotherapy for cancer

F Fang, W Xiao, Z Tian - Seminars in immunology, 2017 - Elsevier
Natural killer (NK) cells can induce an antigen-independent immune response against
malignant cells. A growing number of scientific reports and clinical studies have shown …