Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy
The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …
[HTML][HTML] Improving cell and gene therapy safety and performance using next-generation Nanoplasmid vectors
JA Williams, PA Paez - Molecular Therapy-Nucleic Acids, 2023 - cell.com
The cell and gene therapy industry has employed the same plasmid technology for decades
in vaccination, cell and gene therapy, and as a raw material in viral vector and RNA …
in vaccination, cell and gene therapy, and as a raw material in viral vector and RNA …
[HTML][HTML] Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells
CF Magnani, R Myburgh, S Brunn… - Molecular Therapy …, 2023 - cell.com
Discrimination between hematopoietic stem cells and leukemic stem cells remains a major
challenge for acute myeloid leukemia immunotherapy. CAR T cells specific for the CD117 …
challenge for acute myeloid leukemia immunotherapy. CAR T cells specific for the CD117 …
Heterologous survey of 130 DNA transposons in human cells highlights their functional divergence and expands the genome engineering toolbox
Experimental studies on DNA transposable elements (TEs) have been limited in scale,
leading to a lack of understanding of the factors influencing transposition activity …
leading to a lack of understanding of the factors influencing transposition activity …
[HTML][HTML] Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers
T Chinsuwan, K Hirabayashi, S Mishima… - Molecular Therapy …, 2023 - cell.com
Epidermal growth factor receptor (EGFR) is overexpressed in various cancers, including non-
small cell lung cancer (NSCLC), and in some somatic cells at a limited level, rendering it an …
small cell lung cancer (NSCLC), and in some somatic cells at a limited level, rendering it an …
[HTML][HTML] Chimeric antigen receptor T-cells: Emerging uses and future directions
D Dive, P Content - pharmaphorum.com
Genetic engineering technologies allow for the creation of custom-made cells that can have
transformative effects on human health. This is best exemplified by chimeric antigen receptor …
transformative effects on human health. This is best exemplified by chimeric antigen receptor …