Deep learning-enabled virtual histological staining of biological samples

B Bai, X Yang, Y Li, Y Zhang, N Pillar… - Light: Science & …, 2023 - nature.com
Histological staining is the gold standard for tissue examination in clinical pathology and life-
science research, which visualizes the tissue and cellular structures using chromatic dyes or …

Deep learning in mesoscale brain microscopy image analysis: A review

R Chen, M Liu, W Chen, Y Wang, E Meijering - Computers in Biology and …, 2023 - Elsevier
Mesoscale microscopy images of the brain contain a wealth of information which can help
us understand the working mechanisms of the brain. However, it is a challenging task to …

[HTML][HTML] Label-free virtual HER2 immunohistochemical staining of breast tissue using deep learning

B DoanNgan, DM Angus, LH Sung - BME frontiers, 2022 - spj.science.org
The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2
(HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies, and …

Label-and slide-free tissue histology using 3D epi-mode quantitative phase imaging and virtual hematoxylin and eosin staining

TM Abraham, PC Costa, C Filan, Z Guang, Z Zhang… - Optica, 2023 - opg.optica.org
Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining,
serves as the benchmark for disease diagnosis and comprehensive clinical assessment of …

Virtual stain transfer in histology via cascaded deep neural networks

X Yang, B Bai, Y Zhang, Y Li, K de Haan, T Liu… - ACS …, 2022 - ACS Publications
Pathological diagnosis relies on the visual inspection of histologically stained thin tissue
specimens, where different types of stains are applied to bring contrast to and highlight …

Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy

MT Martell, NJM Haven, BD Cikaluk, BS Restall… - Nature …, 2023 - nature.com
The goal of oncologic surgeries is complete tumor resection, yet positive margins are
frequently found postoperatively using gold standard H&E-stained histology methods …

DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology

L Jin, Y Tang, JB Coole, MT Tan, X Zhao… - Nature …, 2024 - nature.com
Histopathology plays a critical role in the diagnosis and surgical management of cancer.
However, access to histopathology services, especially frozen section pathology during …

Rapid and label-free histological imaging of unprocessed surgical tissues via dark-field reflectance ultraviolet microscopy

S Ye, J Zou, C Huang, F Xiang, Z Wen, N Wang, J Yu… - iScience, 2023 - cell.com
Routine examination for intraoperative histopathologic assessment is lengthy and laborious.
Here, we present the dark-field reflectance ultraviolet microscopy (DRUM) that enables label …

[HTML][HTML] Virtual staining of defocused autofluorescence images of unlabeled tissue using deep neural networks

Y Zhang, L Huang, T Liu, K Cheng, K de Haan… - Intelligent …, 2022 - spj.science.org
Deep learning-based virtual staining was developed to introduce image contrast to label-
free tissue sections, digitally matching the histological staining, which is time-consuming …

Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

WY Park, J Yun, J Shin, BH Oh, G Yoon, SM Hong… - Elife, 2024 - elifesciences.org
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds
promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained …