The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …

Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …

There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

Importance Diverse models have been developed to predict psychosis in patients with
clinical high-risk (CHR) states. Whether prediction can be improved by efficiently combining …

This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …

Importance Family and genetic approaches have traditionally been used to evaluate our
diagnostic concepts. Using a novel method, the family genetic risk score (FGRS), can we …

Importance Schizophrenia is a clinically heterogeneous disorder. It is currently unclear how
variability in symptom dimensions and cognitive ability is associated with genetic liability for …

Over the last years, the decreased costs and enhanced accessibility to large genome-wide
association studies datasets have laid the foundations for the development of polygenic risk …

Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …