Animal models of Parkinson's disease: a guide to selecting the optimal model for your research
Parkinson's disease (PD) is a complex, multisystem disorder characterised by α-synuclein
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …
Animal models of the non-motor features of Parkinson's disease
K McDowell, MF Chesselet - Neurobiology of disease, 2012 - Elsevier
The non-motor symptoms (NMS) of Parkinson's disease (PD) occur in roughly 90% of
patients, have a profound negative impact on their quality of life, and often go undiagnosed …
patients, have a profound negative impact on their quality of life, and often go undiagnosed …
Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys
The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal
ganglia (BG) network and together innervate BG downstream structures using GABA and …
ganglia (BG) network and together innervate BG downstream structures using GABA and …
The role of prefrontal catecholamines in attention and working memory
KL Clark, B Noudoost - Frontiers in neural circuits, 2014 - frontiersin.org
While much progress has been made in identifying the brain regions and neurochemical
systems involved in the cognitive processes disrupted in mental illnesses, to date, the level …
systems involved in the cognitive processes disrupted in mental illnesses, to date, the level …
Subcircuit-specific neuromodulation in the prefrontal cortex
N Dembrow, D Johnston - Frontiers in neural circuits, 2014 - frontiersin.org
During goal-directed behavior, the prefrontal cortex (PFC) exerts top-down control over
numerous cortical and subcortical regions. PFC dysfunction has been linked to many …
numerous cortical and subcortical regions. PFC dysfunction has been linked to many …
The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future
SH Fox, JM Brotchie - Progress in brain research, 2010 - Elsevier
Non-human primate (NHP) models of Parkinson's disease (PD) have been essential in
understanding the pathophysiology and neural mechanisms underlying PD. The most …
understanding the pathophysiology and neural mechanisms underlying PD. The most …
Frontal-striatal circuit functions: context, sequence, and consequence
JA Saint-Cyr - Journal of the International Neuropsychological …, 2003 - cambridge.org
The exact role of the basal ganglia in both the motor and non-motor domains has proven
elusive since it is virtually impossible to refer to its function in isolation of cortical, and …
elusive since it is virtually impossible to refer to its function in isolation of cortical, and …
Executive impairment in Parkinson's disease: response automaticity and task switching
Patients with Parkinson's disease (PD) show slowed movement initiation and can have
deficits in executive function, leading to impairments in controlling involuntary behavior. This …
deficits in executive function, leading to impairments in controlling involuntary behavior. This …
[HTML][HTML] Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series
Inflammation has been linked to the development of nonmotor symptoms in Parkinson's
disease (PD), which greatly impact patients' quality of life and can often precede motor …
disease (PD), which greatly impact patients' quality of life and can often precede motor …
Stress-level cortisol treatment impairs inhibitory control of behavior in monkeys
DM Lyons, JM Lopez, C Yang… - Journal of …, 2000 - Soc Neuroscience
Most studies of cortisol-induced cognitive impairments have focused on hippocampal-
dependent memory. This study investigates a different aspect of cognition in a randomized …
dependent memory. This study investigates a different aspect of cognition in a randomized …