Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy
Z Xu, X Han, D Ou, T Liu, Z Li, G Jiang, J Liu… - Applied microbiology …, 2020 - Springer
Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
Targeting autophagy to sensitive glioma to temozolomide treatment
Y Yan, Z Xu, S Dai, L Qian, L Sun, Z Gong - Journal of experimental & …, 2016 - Springer
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …
Therapeutic targeting of autophagy in disease: biology and pharmacology
Y Cheng, X Ren, WN Hait, JM Yang, Q Ma - Pharmacological reviews, 2013 - Elsevier
Autophagy, a process of self-digestion of the cytoplasm and organelles through which
cellular components are recycled for reuse or energy production, is an evolutionarily …
cellular components are recycled for reuse or energy production, is an evolutionarily …
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells
The aggressiveness of glioblastoma multiforme (GBM) is defined by local invasion and
resistance to therapy. Within established GBM, a subpopulation of tumor-initiating cells with …
resistance to therapy. Within established GBM, a subpopulation of tumor-initiating cells with …
Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro
P Yu, H Wang, M Tian, A Li, X Chen, X Wang… - Acta Pharmacologica …, 2019 - nature.com
Eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulator of protein synthesis,
has been shown to play an important role in modulating autophagy and apoptosis in tumor …
has been shown to play an important role in modulating autophagy and apoptosis in tumor …
[HTML][HTML] CXCL10 and CCL21 promote migration of pancreatic cancer cells toward sensory neurons and neural remodeling in tumors in mice, associated with pain in …
M Hirth, J Gandla, C Höper, MM Gaida, N Agarwal… - Gastroenterology, 2020 - Elsevier
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is frequently accompanied
by excruciating pain, which has been associated with attraction of cancer cells and their …
by excruciating pain, which has been associated with attraction of cancer cells and their …
Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles
Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-
kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the …
kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the …
Cell death pathways and viruses: role of microRNAs
Viral infections lead to the death of more than a million people each year around the world,
both directly and indirectly. Viruses interfere with many cell functions, particularly critical …
both directly and indirectly. Viruses interfere with many cell functions, particularly critical …