The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Primary aldosteronism affects≈ 5% to 10% of hypertensive patients and has unilateral and
bilateral forms. Most unilateral primary aldosteronism is caused by computed tomography …

Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome
P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the …

Context Somatic mutations have been identified in more than half of aldosterone-producing
adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Background: Both aging and inappropriate secretion of aldosterone increase the risk for
developing cardiovascular disease; however, the influence of aging on aldosterone …

Context: Approximately half of patients with primary aldosteronism (PA) have clinically
evident disease according to clinical (hypertension) and/or laboratory (aldosterone and …