Abstract Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …

Diabetes is a common metabolic disease characterized by an imbalance in blood glucose
levels. The pathogenesis of diabetes involves the essential role of cytokines, particularly the …

While inflammation is beneficial for insulin secretion during homeostasis, its transformation
adversely affects β-cells and contributes to diabetes. However, the regulation of islet …

Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1
diabetes (T1D), but the effect of IFN-α on the antigen repertoire of HLA Class I (HLA-I) in …

Zinc is an essential component of the insulin protein complex synthesized in β cells. The
intracellular compartmentalization and distribution of zinc are controlled by 24 …

Comprehensive molecular and cellular phenotyping of human islets can enable deep
mechanistic insights for diabetes research. We established the Human Islet Data Analysis …

Integration of single-cell RNA-sequencing (scRNA-seq) datasets has become a standard
part of the analysis, with conditional variational autoencoders (cVAE) being among the most …

Patients with type 2 and type 1 diabetes (T2D and T1D) exhibit sex-specific differences in
insulin secretion, the mechanisms of which are unknown. We examined sex differences in …

Type 2 and type 1 diabetes (T2D, T1D) exhibit sex differences in insulin secretion, the
mechanisms of which are unknown. We examined sex differences in human pancreatic …

Introduction Immune cells were recently shown to support β-cells and insulin secretion.
However, little is known about how islet immune cells are regulated to maintain glucose …