Successful regeneration of cartilage tissue at a clinical scale has been a tremendous
challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery …

With the plethora of omics data becoming available for mammalian cell and, increasingly,
human cell systems, Genome-scale metabolic models (GEMs) have emerged as a useful …

Fermentation technology is commonly used as a mature process to produce numerous
products with the help of micro-organisms. However, these organisms are sometimes …

Mammalian cells produce up to 80% of the commercially available therapeutic proteins, with
Chinese Hamster Ovary (CHO) cells being the primary production host. Manufacturing …

The production of monoclonal antibodies (mAbs) using Chinese Hamster Ovary (CHO) cells
has revolutionized the treatment of numerous diseases, solidifying their position as a …

Chinese hamster ovary (CHO) cells are widely used for manufacturing antibody drugs. We
attempted to clone a novel high-expression promoter for producing monoclonal antibodies …

The concept of intensified design of experiments allows a faster screening of the given
design space with the risk to introduce an irreversible impact of previous parameter settings …

Fed-batch cell culture processes are common in the biomanufacturing industry due to their
ease of development and simplicity of execution in the cGMP environment. One challenge of …

Chinese hamster ovary (CHO) cells play an important role in the biopharmaceutical industry,
but their production efficiency requires enhancement to meet the growing market demands …

In high-efficiency smart biomanufacturing, continuous monitoring of products, byproducts,
and reagents is crucial for optimizing production processes, improving yield, and ensuring …