Emerging connections between cerebellar development, behaviour and complex brain disorders

A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …

Computational principles of supervised learning in the cerebellum

JL Raymond, JF Medina - Annual review of neuroscience, 2018 - annualreviews.org
Supervised learning plays a key role in the operation of many biological and artificial neural
networks. Analysis of the computations underlying supervised learning is facilitated by the …

Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution

SG Rodriques, RR Stickels, A Goeva, CA Martin… - Science, 2019 - science.org
Spatial positions of cells in tissues strongly influence function, yet a high-throughput,
genome-wide readout of gene expression with cellular resolution is lacking. We developed …

Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

H Fujita, T Kodama, S Du Lac - Elife, 2020 - elifesciences.org
The cerebellar vermis, long associated with axial motor control, has been implicated in a
surprising range of neuropsychiatric disorders and cognitive and affective functions …

Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits

NL Cerminara, EJ Lang, RV Sillitoe… - Nature Reviews …, 2015 - nature.com
The adult mammalian cerebellar cortex is generally assumed to have a uniform
cytoarchitecture. Differences in cerebellar function are thought to arise primarily through …

Consensus paper: experimental neurostimulation of the cerebellum

LN Miterko, KB Baker, J Beckinghausen, LV Bradnam… - The Cerebellum, 2019 - Springer
The cerebellum is best known for its role in controlling motor behaviors. However, recent
work supports the view that it also influences non-motor behaviors. The contribution of the …

Cerebellar modules and their role as operational cerebellar processing units

R Apps, R Hawkes, S Aoki, F Bengtsson, AM Brown… - The Cerebellum, 2018 - Springer
The compartmentalization of the cerebellum into modules is often used to discuss its
function. What, exactly, can be considered a module, how do they operate, can they be …

Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients

LC Bartelt, PM Switonski, G Adamek, F Longo… - Science Translational …, 2024 - science.org
Spinocerebellar ataxia type 7 (SCA7) is a genetic neurodegenerative disorder caused by a
CAG-polyglutamine repeat expansion. Purkinje cells (PCs) are central to the pathology of …

Insights into cerebellar development and connectivity

J Beckinghausen, RV Sillitoe - Neuroscience letters, 2019 - Elsevier
The cerebellum has a well-established role in controlling motor functions such coordination,
balance, posture, and skilled learning. There is mounting evidence that it might also play a …