[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …
incremental scientific work and all positive socio-political engagements, are steps taken in …
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi
Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …
expression representing an attractive and validated target for antibiotics. Two well-known …
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics
Antibiotic development based on natural products has faced a long lasting decline since the
1970s, while both the speed and the extent of antimicrobial resistance (AMR) development …
1970s, while both the speed and the extent of antimicrobial resistance (AMR) development …
C-Ribosylating Enzymes in the (Bio)Synthesis of C-Nucleosides and C-Glycosylated Natural Products
M Pfeiffer, B Nidetzky - ACS Catalysis, 2023 - ACS Publications
Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …
Development and research progress of anti-drug resistant bacteria drugs
X Cui, Y Lü, C Yue - Infection and drug resistance, 2021 - Taylor & Francis
Bacterial resistance has become increasingly serious because of the widespread use and
abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a …
abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a …
A structural view on medicinal chemistry strategies against drug resistance
The natural phenomenon of drug resistance is a widespread issue that hampers the
performance of drugs in many major clinical indications. Antibacterial and antifungal drugs …
performance of drugs in many major clinical indications. Antibacterial and antifungal drugs …
Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments
Epidemic diseases and antibiotic resistance are urgent threats to global health, and human
is confronted with an unprecedented dilemma to conquer them by expediting development …
is confronted with an unprecedented dilemma to conquer them by expediting development …
Tridecaptin M, a New Variant Discovered in Mud Bacterium, Shows Activity against Colistin- and Extremely Drug-Resistant Enterobacteriaceae
ABSTRACT The World Health Organization has categorized the Gram-negative superbugs,
which are inherently impervious to many antibiotics, as critical priority pathogens due to the …
which are inherently impervious to many antibiotics, as critical priority pathogens due to the …
Antimicrobial properties of the novel bacterial isolate Paenibacilllus sp. SMB1 from a halo-alkaline lake in India
Antibiotic-resistance is ever growing burden on our society for the past many years. Many
synthetic chemistry approaches and rational drug-design have been unable to pace up and …
synthetic chemistry approaches and rational drug-design have been unable to pace up and …
Challenges in targeting mycobacterial ATP synthase: The known and beyond
M Mapari, RP Bhole, PB Khedekar… - Journal of Molecular …, 2022 - Elsevier
Abstract Adenosine Triphosphate synthase (ATPs) is an important enzyme for the synthesis
of adenosine triphosphate (ATP). ATP is principal source of energy for growth and …
of adenosine triphosphate (ATP). ATP is principal source of energy for growth and …