In living cells enzymes catalyze a wide variety of metabolic processes, which involve
multiple reaction steps. Efficient transfer of the intermediates from one catalytic site to the …

Age-related neurodegenerative diseases are associated with mild impairment of oxidative
metabolism and accumulation of abnormal proteins. Within the cell, the mitochondria …

Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell
death caused by a multitude of pathological conditions. The molecular sites of mitochondrial …

It has been hypothesized that the high metabolic flux in the mitochondria is due to the self‐
assembly of enzyme supercomplexes (called metabolons) that channel substrates from one …

The interplay among reactive oxygen species (ROS) formation, elevated intracellular
calcium concentration and mitochondrial demise is a recurring theme in research focusing …

Protein–protein interactions or protein complexes are integral in nearly all cellular
processes, ranging from metabolism to structure. Elucidating both individual protein …

Supramolecular assembly of enzymes into metabolon structures is thought to enable
efficient transport of reactants between active sites via substrate channeling. Recombinant …

Succinate: quinone reductase (SQR) of Complex II, occupying a unique central point in the
mitochondrial respiratory system as a major source of electrons driving reactive oxygen …

Molecular hydrogen (H2) can be produced via hydrogenases during mixed-acid
fermentation by bacteria. Escherichia coli possesses multiple (four) hydrogenases …

During erythroid differentiation, the erythron must remodel its protein constituents so that the
mature red cell contains hemoglobin as the chief cytoplasmic protein component. For this,∼ …