Various frameworks and methods, such as quality by design (QbD), real time release test
(RTRT), and continuous process verification (CPV), have been introduced to improve drug …

Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …

Crystallization, as a solid–liquid separation process, is employed to purify and isolate a
great diversity of crystalline pharmaceutical products. In recent years, continuous …

Abstract Aflatoxin B 1 (AFB 1) is the most widely distributed, most toxic, and most harmful,
and it is widely present in moldy grains. This study proposes a new method for quantitative …

Near infrared (NIR) spectroscopy has been widely recognized as a powerful PAT tool for
monitoring blend uniformity in continuous manufacturing (CM) processes. However, the …

Quality is the lifeline for all pharmaceuticals. Process analytical technology (PAT),
introduced by FDA in 2004, providing significant opportunities for improving pharmaceutical …

Reflectance spectroscopy is an excellent candidate for process analytical technology (PAT)
applications in continuous manufacturing of pharmaceutical tablets. Spectroscopic methods …

In-line measurements of low dose blends in the feed frame of a tablet press were performed
for API concentration levels as low as 0.10% w/w. The proposed methodology utilizes the …

The feed frame is a force-feeding device used in the die filling process. The die filling
process is crucial within pharmaceutical manufacturing to guarantee the critical quality …

This study describes the development of a near infrared (NIR) calibration model for real time
determination of drug concentration, powder density, and porosity or relative specific void …