Abstract Derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming somatic
cells to a pluripotent state has revolutionized stem cell research. Ensuing this, various …

The role of p53 as “a guardian of the genome” has been well established in somatic cells.
However, its role in pluripotent stem cells remains much more elusive. Here, we discuss …

Primary and secondary traumatic brain injury (TBI) can cause tissue damage by inducing
cell death pathways including apoptosis, necroptosis, and autophagy. However, similar …

Abstract Background Pancreatic progenitors (PPs) co-expressing the two transcription
factors (TFs) PDX1 and NKX6. 1 are recognized as the indispensable precursors of …

DNA damage is associated with aging and neurological disorders, including Alzheimer's
disease. Isoflurane is a commonly used anesthetic. It remains largely unknown whether …

Remarkably, the p53 transcription factor, referred to as “the guardian of the genome”, is not
essential for mammalian development. Moreover, efforts to identify p53-dependent …

Highlights•The pluripotent state has a unique cell cycle relative to somatic cells.•Extensive
reciprocal crosstalk exists to maintain both pluripotency and a rapid cell cycle.•Unique cell …

Mesenchymal stromal cells (MSCs) have a wide range of therapeutic applications due to
their multipotency, immunomodulatory, and anti-inflammatory properties. Their ability to …

Cells of the inner cell mass (ICM) acquire a unique ability for unlimited self-renewal during
transition into embryonic stem cells (ESCs) in vitro, while preserving their natural multi …

In radiation therapy, adverse side effects are often induced due to the excessive cell death
that occurs in radiosensitive normal cells. The radiation-induced cell death of normal cells is …