N‐acetylcysteine: a review of clinical usefulness (an old drug with new tricks)
GK Schwalfenberg - Journal of nutrition and metabolism, 2021 - Wiley Online Library
Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …
Inherited retinal dystrophies: role of oxidative stress and inflammation in their physiopathology and therapeutic implications
I Pinilla, V Maneu, L Campello, L Fernández-Sánchez… - Antioxidants, 2022 - mdpi.com
Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …
heterogeneous diseases characterized by the progressive degeneration of the retina …
Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration
Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in
neurodegenerative disease. Here, we find that a key consequence of ROS and neuronal …
neurodegenerative disease. Here, we find that a key consequence of ROS and neuronal …
Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila
Declining insect population sizes are provoking grave concern around the world as insects
play essential roles in food production and ecosystems. Environmental contamination by …
play essential roles in food production and ecosystems. Environmental contamination by …
Inherited retinal degenerations: current landscape and knowledge gaps
Inherited retinal degenerations (IRDs) represent a diverse group of progressive, visually
debilitating diseases that can lead to blindness in which mutations in genes that are critical …
debilitating diseases that can lead to blindness in which mutations in genes that are critical …
NAMPT-mediated NAD+ biosynthesis is essential for vision in mice
Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying
pathogenic mechanisms in these diseases may offer global approaches for facilitating …
pathogenic mechanisms in these diseases may offer global approaches for facilitating …
Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy
p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy.
Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene …
Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene …
Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies
Large-scale insecticide application is a primary weapon in the control of insect pests in
agriculture. However, a growing body of evidence indicates that it is contributing to the …
agriculture. However, a growing body of evidence indicates that it is contributing to the …
Platinum nanoparticles enhance exosome release in human lung epithelial adenocarcinoma cancer cells (A549): oxidative stress and the ceramide pathway are key …
S Gurunathan, MH Kang, M Jeyaraj… - International Journal of …, 2021 - Taylor & Francis
Background Several studies have demonstrated various molecular mechanisms involved in
the biogenesis and release of exosomes. However, how external stimuli, such as platinum …
the biogenesis and release of exosomes. However, how external stimuli, such as platinum …
Nutritional and medical food therapies for diabetic retinopathy
Diabetic retinopathy (DR) is a form of microangiopathy. Reducing oxidative stress in the
mitochondria and cell membranes decreases ischemic injury and end-organ damage to the …
mitochondria and cell membranes decreases ischemic injury and end-organ damage to the …