Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Abstract Staining with Congo Red (CR) is a qualitative method used for the identification of
amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained …

When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

It has become common to reference “pi-stacking” forces or “pi–pi interactions” when
describing the interactions between neighbouring aromatic rings. Here, we review …

The aggregation of misfolded proteins is associated with the perturbation of cellular function,
ageing and various human disorders. Mounting evidence suggests that protein aggregation …

Amyloid refers to insoluble protein aggregates that are responsible for amyloid diseases but
are also implicated in important physiological functions (functional amyloids). The …

Protein aggregation is a widespread phenomenon with important implications in many
scientific areas. Although amyloid formation is typically considered as detrimental, functional …

Soluble oligomeric aggregates of the amyloid-β peptide (Aβ) have been implicated in the
pathogenesis of Alzheimer's disease (AD). Although the conformation adopted by Aβ within …

Many, perhaps most, proteins, are capable of forming self-propagating, β-sheet (amyloid)
aggregates. Amyloid-like aggregates are found in a wide range of diseases and underlie …

Intrinsically disordered proteins (IDPs) are a unique class of proteins that have no stable
native structure, a feature that allows them to adopt a wide variety of extended and compact …