Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics

Q Peng, Y Zhou, L Oyang, N Wu, Y Tang, M Su, X Luo… - Molecular Therapy, 2022 - cell.com
Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …

Viral modulation of cellular RNA alternative splicing: a new key player in virus–host interactions?

S Boudreault, P Roy, G Lemay… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain
control of vital cellular functions, the result of which will ultimately dictate the fate of the host …

Plasma cell-free RNA characteristics in COVID-19 patients

Y Wang, J Li, L Zhang, HX Sun, Z Zhang, J Xu… - Genome …, 2022 - genome.cshlp.org
The pathogenesis of COVID-19 is still elusive, which impedes disease progression
prediction, differential diagnosis, and targeted therapy. Plasma cell-free RNAs (cfRNAs) …

Reovirus μ2 protein modulates host cell alternative splicing by reducing protein levels of U5 snRNP core components

S Boudreault, M Durand, CA Martineau… - Nucleic Acids …, 2022 - academic.oup.com
Mammalian orthoreovirus (MRV) is a double-stranded RNA virus from the Reoviridae family
presenting a promising activity as an oncolytic virus. Recent studies have underlined MRV's …

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

C Vandermeulen, T O'grady, J Wayet, B Galvan… - PLoS …, 2021 - journals.plos.org
Viral infections are known to hijack the transcription and translation of the host cell.
However, the extent to which viral proteins coordinate these perturbations remains unclear …

Virus-induced transposable element expression up-regulation in human and mouse host cells

MG Macchietto, RA Langlois… - Life science …, 2020 - life-science-alliance.org
Virus–host cell interactions initiate a host cell–defensive response during virus infection.
How transposable elements in the host cell respond to viral stress at the molecular level …

Role of SARS-CoV-2 in altering the RNA-binding protein and miRNA-directed post-transcriptional regulatory networks in humans

R Srivastava, SV Daulatabad, M Srivastava… - International journal of …, 2020 - mdpi.com
The outbreak of a novel coronavirus SARS-CoV-2 responsible for the COVID-19 pandemic
has caused a worldwide public health emergency. Due to the constantly evolving nature of …

From gene to protein—How bacterial virulence factors manipulate host gene expression during infection

L Denzer, H Schroten, C Schwerk - International Journal of Molecular …, 2020 - mdpi.com
Bacteria evolved many strategies to survive and persist within host cells. Secretion of
bacterial effectors enables bacteria not only to enter the host cell but also to manipulate host …

[HTML][HTML] Modifications of lipid pathways restrict SARS-CoV-2 propagation in human induced pluripotent stem cell-derived 3D airway organoids

PH Tsai, JR Sun, Y Chien, MS Chan, W Khor… - Journal of Advanced …, 2024 - Elsevier
Background Modifications of lipid metabolism were closely associated with the
manifestations and prognosis of coronavirus disease of 2019 (COVID-19). Pre-existing …

Dengue virus pathogenesis and host molecular machineries

S Sinha, K Singh, YS Ravi Kumar, R Roy… - Journal of Biomedical …, 2024 - Springer
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae
family. DENV is the causative agent of dengue, the most rapidly spreading viral disease …