[HTML][HTML] Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects
R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …
[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …
production, viral RNA and a sustained interferon (IFN) response, all of which are …
[HTML][HTML] Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing
W Wen, W Su, H Tang, W Le, X Zhang, Y Zheng, X Liu… - Cell discovery, 2020 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, has recently affected over 1,200,000 people
and killed more than 60,000. The key immune cell subsets change and their states during …
and killed more than 60,000. The key immune cell subsets change and their states during …
[HTML][HTML] The NLRP3 inflammasome: an overview of mechanisms of activation and regulation
N Kelley, D Jeltema, Y Duan, Y He - International journal of molecular …, 2019 - mdpi.com
The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …
A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …
the host through recognition of distinct molecules, known as pathogen-or damage …
The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
M Zheng, TD Kanneganti - Immunological reviews, 2020 - Wiley Online Library
ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
[HTML][HTML] Influenza virus-related critical illness: pathophysiology and epidemiology
Influenza virus affects the respiratory tract by direct viral infection or by damage from the
immune system response. In humans, the respiratory epithelium is the only site where the …
immune system response. In humans, the respiratory epithelium is the only site where the …
[HTML][HTML] The PANoptosome: a deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis)
Programmed cell death is regulated by evolutionarily conserved pathways that play critical
roles in development and the immune response. A newly recognized pathway for …
roles in development and the immune response. A newly recognized pathway for …
Coronaviruses: innate immunity, inflammasome activation, inflammatory cell death, and cytokines
The innate immune system acts as the first line of defense against pathogens, including
coronaviruses (CoVs). Severe acute respiratory syndrome (SARS)-CoV and Middle East …
coronaviruses (CoVs). Severe acute respiratory syndrome (SARS)-CoV and Middle East …