Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …

The inherited platelet disorders are an uncommon cause of symptomatic bleeding. They
may be difficult to diagnose (and are likely to be under‐diagnosed) and pose problems in …

The guideline writing group was selected to be representative of UK‐based medical experts.
MEDLINE was systematically searched for publications in English up to the Summer of 2010 …

Background: Platelets have three major types of secretory organelles: lysosomes, dense
granules, and α‐granules. α‐Granules contain several adhesive proteins involved in …

Genetic defects of the megakaryocyte lineage give rise to bleeding syndromes of varying
severity. Blood platelets are unable to fulfill their hemostatic function of preventing blood loss …

The gray platelet syndrome (GPS) is a rare inherited disorder of the megakaryocyte (MK)
lineage. Thrombocytopenia and enlarged platelets are associated with a specific absence of …

Activated platelets release their granule content in a concentrated fashion at sites of injury.
We examined whether ectopically expressed factor VIII in developing megakaryocytes …

Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis - PMC
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BACKGROUND Fibrinogen is a large (340 kDa) hexameric glycoprotein expressed by
hepatocytes. 1 Fibrinogen is encoded by 3 different genes (FGA, FGB, and FGG) and …

Bleeding problems are associated with defects in platelet α-granules, yet little is known
about how these granules are formed and released. Mutations affecting VPS33B, a novel …