Connexins: synthesis, post-translational modifications, and trafficking in health and disease
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …
direct intercellular communication, a critical feature for the development, function, and …
Connexins: key players in the control of vascular plasticity and function
U Pohl - Physiological reviews, 2020 - journals.physiology.org
Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …
Protein–protein interactions with connexin 43: Regulation and function
Connexins are integral membrane building blocks that form gap junctions, enabling direct
cytoplasmic exchange of ions and low-molecular-mass metabolites between adjacent cells …
cytoplasmic exchange of ions and low-molecular-mass metabolites between adjacent cells …
Cellular mechanisms of connexin-based inherited diseases
The 21-member connexin gene family exhibits distinct tissue expression patterns that can
cause a diverse array of over 30 inherited connexin-linked diseases ranging from deafness …
cause a diverse array of over 30 inherited connexin-linked diseases ranging from deafness …
Connexins in astrocyte migration
R Lagos-Cabré, F Burgos-Bravo, AM Avalos… - Frontiers in …, 2020 - frontiersin.org
Astrocytes have long been considered the supportive cells of the central nervous system, but
during the last decades, they have gained much more attention because of their active …
during the last decades, they have gained much more attention because of their active …
Mechanisms of connexin regulating peptides
Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …
found to be involved in multiple pathophysiological states from cancer to cardiovascular …
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells
Classically associated with gap junction-mediated intercellular communication, connexin43
(Cx43) is increasingly recognized to possess non-canonical biological functions, including …
(Cx43) is increasingly recognized to possess non-canonical biological functions, including …
Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease
GW Price, CE Chadjichristos, P Kavvadas… - Cell Communication and …, 2020 - Springer
Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic
Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated …
Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated …
Interaction of α carboxyl terminus 1 peptide with the connexin 43 carboxyl terminus preserves left ventricular function after ischemia‐reperfusion injury
J Jiang, D Hoagland, JA Palatinus, H He… - Journal of the …, 2019 - Am Heart Assoc
Background α Carboxyl terminus 1 (α CT 1) is a 25–amino acid therapeutic peptide
incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is …
incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is …
Electrical synaptic transmission requires a postsynaptic scaffolding protein
AM Lasseigne, FA Echeverry, S Ijaz, JC Michel… - Elife, 2021 - elifesciences.org
Electrical synaptic transmission relies on neuronal gap junctions containing channels
constructed by Connexins. While at chemical synapses neurotransmitter-gated ion channels …
constructed by Connexins. While at chemical synapses neurotransmitter-gated ion channels …