Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of
cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal …

Clinical use of doxorubicin (DOX) is limited because of its cardiotoxicity, referred to as DOX-
induced cardiomyopathy (DIC). Mitochondria-dependent ferroptosis, which is triggered by …

Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Cardiomyopathies are a clinically heterogeneous group of cardiac diseases characterized
by heart muscle damage, resulting in myocardium disorders, diminished cardiac function …

The hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is
about 6% and has not decreased in recent years. The leading cause of death of these …

BACKGROUND: Cardiac autoantibodies (cAAbs) are involved in the progression of adverse
cardiac remodeling in heart failure (HF). However, our understanding of cAAbs in HF is …

Cardiovascular disease (CVD) is currently one of the prevalent causes of human death. Iron
is one of the essential trace elements in the human body and a vital component of living …

Background: Dilated cardiomyopathy (DCM) is a life-threatening disease, resulting in
refractory heart failure. An immune disorder underlies the pathophysiology associated with …

Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a
variety of cellular stress states. It is involved in regulating proteostasis and protecting cells …

In conjunction with previous studies, we have noted that ferroptosis, as an emerging mode of
regulated cell death (RCD), is intimately related to anthracycline pharmacotherapy. Not only …