Management of Monogenic and Syndromic Obesity

JC Han, MC Rasmussen, AR Forte… - Gastroenterology …, 2023 - gastro.theclinics.com
The adipocyte-secreted hormone leptin and its downstream signaling mediators within the
central nervous system (Fig. 1) have been fundamental in understanding energy …

Updates on Rare Genetic Variants, Genetic Testing, and Gene Therapy in Individuals With Obesity

MV Zuccaro, CA LeDuc, VV Thaker - Current Obesity Reports, 2024 - Springer
While specific genetic mutations are rare, these segregate in individuals with early-onset
severe obesity; thus, collectively genetic etiologies are not as rare. Some genetic conditions …

[HTML][HTML] The Outcome of Metabolic and Bariatric Surgery in Morbidly Obese Patients with Different Genetic Variants Associated with Obesity: A Systematic Review

M Zafirovska, A Zafirovski, T Režen, T Pintar - Nutrients, 2024 - mdpi.com
Metabolic and bariatric surgery (MBS) effectively treats obesity and related comorbidities,
though individual responses vary. This systematic review examines how genetic variants …

Mutations in the leptin‐melanocortin pathway and weight loss after bariatric surgery: a systematic review and meta‐analysis

N Zhang, H Wang, S Ran, Z Wang, B Zhou, S Wang… - …, 2024 - Wiley Online Library
Objective The objective of this meta‐analysis was to quantify the overall effects of gene
mutations in the leptin‐melanocortin pathway on short‐and long‐term weight loss after …