Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

T cells redirected to specific antigen targets with engineered chimeric antigen receptors
(CARs) are emerging as powerful therapies in hematologic malignancies. Various CAR …

Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer
development and progression. Healthy primary neutrophils present potent cytotoxicity …

T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the
field of cellular therapy for cancer. Despite its success, this strategy has some recognised …

Many B‐cell acute and chronic leukaemias tend to be resistant to killing by natural killer (NK)
cells. The introduction of chimeric antigen receptors (CAR) into T cells or NK cells could …

Cell and gene therapies using haematopoietic stem cells (HSCs) epitomize the
transformative potential of regenerative medicine. Recent clinical successes for gene …

The success of adoptive therapy using chimeric antigen receptor (CAR)–expressing T cells
partly depends on optimal CAR design. CARs frequently incorporate a spacer/linker region …

X-linked hyper-immunoglobulin M (hyper-IgM) syndrome (XHIM) is a primary
immunodeficiency due to mutations in CD40 ligand that affect immunoglobulin class-switch …

Natural killer (NK) lymphocytes are an integral component of the innate immune system and
represent important effector cells in cancer immunotherapy, particularly in the control of …

The proliferation and trafficking of T lymphocytes in immune responses are crucial events in
determining inflammatory responses. To study whole-body T lymphocyte dynamics …