Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …

The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …

Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from
phospholipase-released arachidonic acid that are involved in numerous homeostatic …

Many intriguing facets of lipoxygenase (LOX) catalysis are open to a detailed structural
analysis. Polyunsaturated fatty acids with two to six double bonds are oxygenated precisely …

Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …

5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a
group of pro-inflammatory lipid mediators derived from arachidonic acid. Leukotriene …

Lipoxygenases (LOXs) are lipid peroxidizing enzymes, implicated in the pathogenesis of
inflammatory and hyperproliferative diseases, which represent potential targets for …

As reactive oxygen species (ROS) play critical roles in plants to determine cell fate in various
physiological situations, there is keen interest in the biochemical processes of ROS signal …

Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid
(LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill …