Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Melatonin is mainly produced in the mammalian pineal gland during the dark phase. Its
secretion from the pineal gland has been classically associated with circadian and circanual …

This review aims at describing the beneficial properties of melatonin related to its antioxidant
effects. Oxidative stress, ie, an imbalance between the production of reactive oxygen …

Both melatonin and proteasome inhibitors upregulate antioxidant enzymes including
superoxide dismutase (SOD), glutathione peroxidase (GP), hemoxygenase 1 (HO-1), and …

Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been
reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation …