Targeting the HGF/MET axis in cancer therapy: challenges in resistance and opportunities for improvement
X Huang, E Li, H Shen, X Wang, T Tang… - Frontiers in Cell and …, 2020 - frontiersin.org
Among hundreds of thousands of signal receptors contributing to oncogenic activation,
tumorigenesis, and metastasis, the hepatocyte growth factor (HGF) receptor–also called …
tumorigenesis, and metastasis, the hepatocyte growth factor (HGF) receptor–also called …
Discovery of pyrrolo [2, 3-d] pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
D Xu, D Sun, W Wang, X Peng, Z Zhan, Y Ji… - European Journal of …, 2021 - Elsevier
Axl has emerged as an attractive target for cancer therapy due to its strong correlation with
tumor growth, metastasis, poor survival, and drug resistance. Herein, we report the design …
tumor growth, metastasis, poor survival, and drug resistance. Herein, we report the design …
Identification of a 7H-pyrrolo [2, 3-d] pyrimidin derivatives as selective type II c-Met/Axl inhibitors with potent antitumor efficacy
S Qin, L Xie, M Tang, H Ni, T Yang - Bioorganic Chemistry, 2025 - Elsevier
In this study, we reported the discovery of a novel type II c-Met/Axl inhibitor, characterized by
using 4-amino-7H-pyrrolo [2, 3-d] pyrimidine as a hinge region binder. Through a systematic …
using 4-amino-7H-pyrrolo [2, 3-d] pyrimidine as a hinge region binder. Through a systematic …