Cell-based therapy continues to grow as a new field to explore investigational treatments for
stroke. Leaders from academia and industry convened an inaugural meeting in 2007 with …

Chronic disability after stroke represents a major unmet neurologic need. ReNeuron's
development of a human neural stem cell (hNSC) therapy for chronic disability after stroke is …

Background CTX0E03 is an immortalised human neural stem-cell line from which a drug
product (CTX-DP) was developed for allogeneic therapy. Dose-dependent improvement in …

Objective To assess the safety and efficacy of 2 repeated intrathecal injections of autologous
bone marrow–derived mesenchymal stem cells (BM‐MSCs) in amyotrophic lateral sclerosis …

Transplantation of endothelial progenitor cells (EPCs) is a proven safe and effective method
for treatment of cerebral ischemia in animal experiments. However, safety and efficacy need …

The power of a placebo to effect clinically meaningful neurobiological change comparable to
pharmacological therapies has been demonstrated, although the mechanisms are not fully …

The process of developing new and complex stem-cell-based therapeutics is incremental
and requires decades of sustained collaboration among different stakeholders. In this …

Sham surgery is often required for cell therapies adopting a randomized placebo-controlled
double-blinded trial design. Using the case of dopamine neuron therapy for Parkinson's …

Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for
amyotrophic lateral sclerosis (ALS) clinical trials. There are considerable difficulties in …

Neurosurgical therapeutic interventions include components that are presumed to be
therapeutically inert, such as craniotomy and electrode implantation. Because these …