Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers

D Gagliardi, N Bresolin, GP Comi, S Corti - Cellular and Molecular Life …, 2021 - Springer
Extracellular vesicles (EVs) are small reservoirs of different molecules and important
mediators of cell-to-cell communication. As putative vehicles of misfolded protein …

Emerging roles of extracellular vesicles in neurodegenerative disorders

Y You, T Ikezu - Neurobiology of Disease, 2019 - Elsevier
Extracellular vesicles (EVs) are heterogeneous cell-derived membranous vesicles which
carry a large diversity of molecules such as proteins and RNA species. They are now …

Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients

D Saucier, G Wajnberg, J Roy, AP Beauregard… - Brain Research, 2019 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the
progressive death of motor neurons. Mean survival for a patient diagnosed with ALS is …

The role of vesicle trafficking and release in oligodendrocyte biology

CR Reiter, ER Bongarzone - Neurochemical research, 2020 - Springer
Oligodendrocytes are a subtype of glial cells found within the central nervous system (CNS),
responsible for the formation and maintenance of specialized myelin membranes which …

Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats

P Izquierdo-Altarejos, M Martínez-García… - Cellular and Molecular …, 2023 - Springer
Patients with liver cirrhosis show hyperammonemia and peripheral inflammation and may
show hepatic encephalopathy with cognitive impairment, reproduced by rats with chronic …

Extracellular vesicles in neurological disorders

A Mazurskyy, J Howitt - New Frontiers: Extracellular Vesicles, 2021 - Springer
The role of extracellular vesicles (EVs) in the central nervous system, and in particular the
brain, is a rapidly growing research area. Importantly, the role for EVs in the nervous system …

[PDF][PDF] Plasma extracellular vesicle Tau isoform ratios and TDP-43 inform about molecular pathology in frontotemporal dementia and amyotrophic lateral sclerosis …

M Chatterjee, S Özdemir, C Fritz, W Möbius… - ResSq., 2023 - researchgate.net
Low-invasive biomarkers are urgently needed for the detection of molecular pathology in
Frontotemporal Dementia (FTD), FTD spectrum disorders and Amyotrophic Lateral Sclerosis …

Plasma extracellular vesicle Tau isoform ratios and TDP-43 inform about molecular pathology in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

M Chatterjee, S Özdemir, C Fritz, W Möbius… - 2023 - researchsquare.com
Low-invasive biomarkers are urgently needed for the detection of molecular pathology in
Frontotemporal Dementia (FTD), FTD spectrum disorders and Amyotrophic Lateral Sclerosis …

Extracellular Vesicles as Biomarkers for Neurodegenerative Diseases

L Michels - 2023 - studenttheses.uu.nl
For the development of therapies for neurodegenerative diseases, it is essential to have
validated biomarkers for diagnosis and monitoring disease progression. Finding relevant …