Cardiac glycosides are a diverse family of naturally derived compounds that bind to and
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …

Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

CD4+ T helper lymphocytes that express interleukin-17 (TH17 cells) have critical roles in
mouse models of autoimmunity, and there is mounting evidence that they also influence …

Glycosylation is the most complex post-translational modification of proteins. Altered glycans
on the tumor-and host-cell surface and in the tumor microenvironment have been identified …

Identification of novel indications for commonly prescribed drugs could accelerate
translation of therapies. We investigated whether any clinically used drugs might be useful in …

The proteasomal pathway of protein degradation involves 2 discrete steps: ubiquitination
and degradation. Here, we evaluated the effects of inhibiting the ubiquitination pathway at …

On-patent and off-patent drugs with previously unrecognized anticancer activity could be
rapidly repurposed for this new indication given their prior toxicity testing. To identify such …

Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that
share a steroid‐like structure with an unsaturated lactone ring and the ability to induce …

Complex carbohydrates, which are major components of the cell membrane, perform
important functions in cell-cell and cell-extracellular matrix interactions, as well as in signal …

Gastric cancer has a high incidence and mortality, so there is a pressing need to understand
the underlying molecular mechanisms in order to discover novel biomarkers. Glycosylation …