While fruits and vegetables are recommended for prevention of cancer and other diseases,
their active ingredients (at the molecular level) and their mechanisms of action less well …

MULTIPLE MYELOMA (MM) is a clonal B-cell neo-plasm that affects terminally differentiated
B cells (ie, plasma cells) and may proceed through different phases: an inactive phase in …

We have shown that thalidomide (Thal) and its immunomodulatory derivatives (IMiDs),
proteasome inhibitor PS-341, and As 2 O 3 act directly on multiple myeloma (MM) cells and …

Numerous reports suggest that IL-6 promotes survival and proliferation of multiple myeloma
(MM) cells through the phosphorylation of a cell signaling protein, STAT3. Thus, agents that …

Curcumin derived from the tropical plant Curcuma longa has a long history of use as a
dietary agent, food preservative, and in traditional Asian medicine. It has been used for …

In this study we demonstrate that tumor necrosis factor α (TNFα) triggers only modest
proliferation, as well as p44/p42 mitogen-activated protein kinase (MAPK) and NF-κB …

Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa),
a spice often found in curry powder. In recent years, considerable interest has been focused …

Multiple myeloma (MM) is an incurable B-cell malignancy characterized by accumulation of
malignant plasma cells in bone marrow (BM) and recurrent or persistent infections. Toll-like …

Interleukin-21 (IL-21) is a recently cloned cytokine with homology to IL-2, IL-4, and IL-15. In
this study we examined the effects of IL-21 on human myeloma cells. We found that IL-21 …

Bone morphogenetic proteins (BMPs) can be isolated from organic bone matrix and are able
to initiate de novo cartilage and bone formation. Here it is shown that BMP-4 inhibited DNA …