Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Oral squamous cell carcinoma (OSCC) is the most common cancer in the oral cavity
accounting for 90% of oral cancer with a global incidence of 350.000 new cases per year …

Background The endometrial cancer mismatch repair (MMR) deficient subgroup is defined
by loss of MSH6, MSH2, PMS2 or MLH1. We compare MMR status in paired preoperative …

Cancer initiation and progression are typically associated with the accumulation of driver
mutations and genomic instability. However, recent studies demonstrated that cancer can …

Increased expression of mismatch repair proteins often correlates with tumor
aggressiveness. Chakraborty, Dinh, and Alani report that co-overexpression of Msh2 and …

Objective Many patients treated with immune checkpoint inhibitors (ICIs) developed primary
or secondary drug resistance for unknown reasons. This study investigates whether …

Simple Summary Androgen deprivation therapy is the most effective and widely used
treatment for advanced prostate cancer, but its efficacy is highly variable among patients …

Recessive dystrophic epidermolysis bullosa (RDEB) is a severely debilitating disorder
caused by pathogenic variants in COL7A1 and is characterized by extreme skin fragility …

Different environmental agents may cause DNA mutations by disrupting its double‐strand
structure; however, even normal DNA polymerase function may synthesize mismatch …

The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the
observation that while cancer cells display widespread mutational burden, acquisition of …