[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
[HTML][HTML] Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
EH Douma, ER de Kloet - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …
motivational, and social reward associations together with their more demanding cognitive …
[HTML][HTML] Dopamine release in the nucleus accumbens core signals perceived saliency
A large body of work has aimed to define the precise information encoded by dopaminergic
projections innervating the nucleus accumbens (NAc). Prevailing models are based on …
projections innervating the nucleus accumbens (NAc). Prevailing models are based on …
Dopamine signaling in the nucleus accumbens core mediates latent inhibition
Studies investigating the neural mechanisms by which associations between cues and
predicted outcomes control behavior often use associative learning frameworks to …
predicted outcomes control behavior often use associative learning frameworks to …
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model
Emotional stress is considered a severe pathogenetic factor of psychiatric disorders.
However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious …
However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious …
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement
The long-range GABAergic input from the ventral tegmental area (VTA) to the nucleus
accumbens (NAc) is relatively understudied, and therefore its role in reward processing has …
accumbens (NAc) is relatively understudied, and therefore its role in reward processing has …
An endogenous opioid circuit determines state-dependent reward consumption
DC Castro, CS Oswell, ET Zhang, CE Pedersen… - Nature, 2021 - nature.com
Abstract µ-Opioid peptide receptor (MOPR) stimulation alters respiration, analgesia and
reward behaviour, and can induce substance abuse and overdose,–. Despite its evident …
reward behaviour, and can induce substance abuse and overdose,–. Despite its evident …
[HTML][HTML] Stress relief as a natural resilience mechanism against depression-like behaviors
Relief, the appetitive state after the termination of aversive stimuli, is evolutionarily
conserved. Understanding the behavioral role of this well-conserved phenomenon and its …
conserved. Understanding the behavioral role of this well-conserved phenomenon and its …
A photoswitchable GPCR-based opsin for presynaptic inhibition
Optical manipulations of genetically defined cell types have generated significant insights
into the dynamics of neural circuits. While optogenetic activation has been relatively …
into the dynamics of neural circuits. While optogenetic activation has been relatively …
An atlas of transcriptionally defined cell populations in the rat ventral tegmental area
The ventral tegmental area (VTA) is a complex brain region that is essential for reward
function and frequently implicated in neuropsychiatric disease. While decades of research …
function and frequently implicated in neuropsychiatric disease. While decades of research …