Despite many advances in diagnosis and therapy (surgery, radiation therapy,
chemotherapy), cancer remains one of the most important public health problems …

Simple Summary In prostate cancer, overdiagnosis and overtreatment is a common problem
for clinicians. Accurate diagnosis and prognosis are essential to avoid unnecessary biopsy …

Importance Potential survival benefits from treating aggressive (Gleason score,≥ 7) early-
stage prostate cancer are undermined by harms from unnecessary prostate biopsy and …

Background: Widespread use of prostate specific antigen (PSA) in screening procedures
allowed early identification of an increasing number of prostate cancers (PCas), mainly …

Recent studies have demonstrated that long noncoding RNAs (lncRNA) have important
roles in cancer biology, and that the downregulation of lncRNA growth arrest–specific …

Purpose: The 4Kscore® test accurately detects aggressive prostate cancer and reduces
unnecessary biopsies. However, its performance in African American men has been …

African American (AA) men exhibit a relatively high incidence and mortality due to prostate
cancer even after adjustment for socioeconomic factors, but the biological basis for this …

Introduction Advances in high-throughput sequencing have greatly advanced our
understanding of long non-coding RNAs (lncRNAs) in a relatively short period of time. This …

Background Several liquid biomarker tests have been developed to account for the
limitations of prostate specific antigen (PSA) screening prior to prostate biopsy. African …

There are numerous tests available that can help increase the specificity of PSA, in the initial
and repeat biopsy setting. All coincide with a small decrease in sensitivity of detecting high …