A paradigm shift in translational psychiatry through rodent neuroethology

Y Shemesh, A Chen - Molecular psychiatry, 2023 - nature.com
Mental disorders are a significant cause of disability worldwide. They profoundly affect
individuals' well-being and impose a substantial financial burden on societies and …

The role of enriched environment in neural development and repair

Y Han, M Yuan, YS Guo, XY Shen, ZK Gao… - Frontiers in cellular …, 2022 - frontiersin.org
In addition to genetic information, environmental factors play an important role in the
structure and function of nervous system and the occurrence and development of some …

What is adult hippocampal neurogenesis good for?

G Kempermann - Frontiers in neuroscience, 2022 - frontiersin.org
Adult hippocampal neurogenesis is a unique and exceptional process in the mammalian
brain that in a lifelong and activity-dependent way generates new excitatory principal …

The molecular effects of environmental enrichment on Alzheimer's disease

AKY Liew, CH Teo, T Soga - Molecular neurobiology, 2022 - Springer
Environmental enrichment (EE) is an environmental paradigm encompassing sensory,
cognitive, and physical stimulation at a heightened level. Previous studies have reported the …

Designing animal-friendly behavioral tests for neuroscience research: the importance of an ethological approach

R d'Isa, R Gerlai - Frontiers in Behavioral Neuroscience, 2023 - frontiersin.org
Behavioral tests have three key elements:(1) a motivating factor (what motivates the animal
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …

[HTML][HTML] The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment

G Kempermann, JB Lopes, S Zocher, S Schilling… - Neurobiology of …, 2022 - Elsevier
Personalized medicine intensifies interest in experimental paradigms that delineate sources
of phenotypic variation. The paradigm of environmental enrichment allows for comparisons …

Adult Neurogenesis in the Human Dentate Gyrus

FH Gage - Hippocampus, 2025 - Wiley Online Library
In the adult dentate gyrus of the hippocampus there are neuronal stem cells that give rise to
immature neurons and subsequently to mature functional granule neurons. The rate of …

Targeting neuronal epigenomes for brain rejuvenation

S Zocher - The EMBO journal, 2024 - embopress.org
Aging is associated with a progressive decline of brain function, and the underlying causes
and possible interventions to prevent this cognitive decline have been the focus of intense …

Adult neurogenesis: A story ranging from controversial new neurogenic areas and human adult neurogenesis to molecular regulation

P Leal-Galicia, ME Chávez-Hernández, F Mata… - International journal of …, 2021 - mdpi.com
The generation of new neurons in the adult brain is a currently accepted phenomenon. Over
the past few decades, the subventricular zone and the hippocampal dentate gyrus have …

Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures

CC Vogt, MN Zipple, DD Sprockett, CH Miller… - BMC biology, 2024 - Springer
Background Social behavior and social organization have major influences on individual
health and fitness. Yet, biomedical research focuses on studying a few genotypes under …