The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer
L Ding, J Cao, W Lin, H Chen, X Xiong, H Ao… - International journal of …, 2020 - mdpi.com
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …
Cyclin-dependent kinases
M Malumbres - Genome biology, 2014 - Springer
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate
subunit-a cyclin-that provides domains essential for enzymatic activity. CDKs play important …
subunit-a cyclin-that provides domains essential for enzymatic activity. CDKs play important …
Differential analysis of gene regulation at transcript resolution with RNA-seq
Differential analysis of gene and transcript expression using high-throughput RNA
sequencing (RNA-seq) is complicated by several sources of measurement variability and …
sequencing (RNA-seq) is complicated by several sources of measurement variability and …
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
M Heidemann, C Hintermair, K Voß, D Eick - Biochimica et Biophysica Acta …, 2013 - Elsevier
The eukaryotic RNA polymerase II (RNAPII) catalyzes the transcription of all protein
encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII …
encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII …
Cell cycle and DNA repair regulation in the damage response: protein phosphatases take over the reins
A Campos, A Clemente-Blanco - International journal of molecular …, 2020 - mdpi.com
Cells are constantly suffering genotoxic stresses that affect the integrity of our genetic
material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission …
material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission …
The writers, readers, and functions of the RNA polymerase II C-terminal domain code
Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …
The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans
P Partscht, E Schiebel - The EMBO Journal, 2023 - embopress.org
CDC14, originally identified as crucial mediator of mitotic exit in budding yeast, belongs to
the family of dual‐specificity phosphatases (DUSPs) that are present in most eukaryotes …
the family of dual‐specificity phosphatases (DUSPs) that are present in most eukaryotes …
[HTML][HTML] Role of protein phosphatases PP1, PP2A, PP4 and Cdc14 in the DNA damage response
F Ramos, MT Villoria, E Alonso-Rodríguez… - Cell stress, 2019 - ncbi.nlm.nih.gov
Maintenance of genome integrity is fundamental for cellular physiology. Our hereditary
information encoded in the DNA is intrinsically susceptible to suffer variations, mostly due to …
information encoded in the DNA is intrinsically susceptible to suffer variations, mostly due to …
Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells
C Villarroya‐Beltri, AFB Martins, A García… - The EMBO …, 2023 - embopress.org
Maintenance of stemness is tightly linked to cell cycle regulation through protein
phosphorylation by cyclin‐dependent kinases (CDKs). However, how this process is …
phosphorylation by cyclin‐dependent kinases (CDKs). However, how this process is …
Massively parallel high-order combinatorial genetics in human cells
The systematic functional analysis of combinatorial genetics has been limited by the
throughput that can be achieved and the order of complexity that can be studied. To enable …
throughput that can be achieved and the order of complexity that can be studied. To enable …