Towards targeting the breast cancer immune microenvironment

MA Harris, P Savas, B Virassamy… - Nature Reviews …, 2024 - nature.com
The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

The impact of sex on HIV immunopathogenesis and therapeutic interventions

E Mihealsick, A Word, EP Scully - The Journal of Clinical Investigation, 2024 - jci.org
Globally, the majority of people living with HIV are women or girls, but they have been a
minority of participants in clinical trials and observational studies of HIV. Despite this …

A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses

DP Chupp, CE Rivera, Y Zhou, Y Xu, PS Ramsey… - Nature …, 2024 - nature.com
Humanized mice are limited in terms of modeling human immunity, particularly with regards
to antibody responses. Here we constructed a humanized (THX) mouse by grafting non-γ …

Immunological clues to sex differences in parasitic diseases

J Sellau, CS Hansen, RI Gálvez, L Linnemann… - Trends in …, 2024 - cell.com
The effect of sex on the prevalence and severity of parasitic diseases is an emerging area of
research. Several factors underlie sex-based differences, including sociocultural influences …

The immune–endocrine interplay in sex differential responses to viral infection and COVID-19

V D'Onofrio, RP Sékaly - Trends in Immunology, 2024 - cell.com
Men are at higher risk for developing severe COVID-19 than women, while women are at
higher risk for developing post-acute sequelae of COVID-19 (PASC). This highlights the …

Macrophage plasticity and function in cancer and pregnancy

T Yin, X Li, Y Li, X Zang, L Liu, M Du - Frontiers in immunology, 2024 - frontiersin.org
As the soil of life, the composition and shaping process of the immune microenvironment of
the uterus is worth exploring. Macrophages, indispensable constituents of the innate …

Immune cells, gut microbiota, and vaccines: a gender perspective

P Rio, M Caldarelli, M Chiantore, F Ocarino, M Candelli… - Cells, 2024 - mdpi.com
The development of preventive and therapeutic vaccines has played a crucial role in
preventing infections and treating chronic and non-communicable diseases, respectively …

Associations of daily eating frequency and nighttime fasting duration with biological aging in National Health and Nutrition Examination Survey (NHANES) 2003–2010 …

X Wang, J Zhang, X Xu, S Pan, L Cheng… - International Journal of …, 2024 - Springer
Background Information on the influences of daily eating frequency (DEF) and nighttime
fasting duration (NFD) on biological aging is minimal. Our study investigated the potential …

The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system

S Gómez-Olarte, V Mailänder… - Biology of …, 2024 - academic.oup.com
Endocrine-disrupting chemicals are natural and synthetic compounds found ubiquitously in
the environment that interfere with the hormonal-immune axis, potentially impacting human …

Conceptualizing disparities and differences in the psychobiology of traumatic stress

KA Correa, V Michopoulos, JS Stevens… - Journal of Traumatic …, 2024 - Wiley Online Library
Understanding biological pathways that mediate trauma‐related psychopathology is a major
goal for traumatic stress studies. There is growing interest in studying differences in neural …