Surgery, neuroinflammation and cognitive impairment

A Alam, Z Hana, Z Jin, KC Suen, D Ma - EBioMedicine, 2018 - thelancet.com
Trauma experienced during surgery can contribute to the development of a systemic
inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical …

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

AL Luo, J Yan, XL Tang, YL Zhao, BY Zhou… - Inflammopharmacology, 2019 - Springer
The aging population is burgeoning globally and this trend presents great challenges to the
current healthcare system as the growing number of aged individuals receives procedures …

Transcutaneous electrical acupoint stimulation for postoperative cognitive dysfunction in geriatric patients with gastrointestinal tumor: a randomized controlled trial

L Xi, F Fang, H Yuan, D Wang - Trials, 2021 - Springer
Background This study aimed to evaluate the effect of perioperative transcutaneous
electrical acupoint stimulation (TEAS) on postoperative cognitive dysfunction (POCD) in …

Effects of anesthetic adjunctive agents on postoperative cognitive dysfunction in elderly patients undergoing noncardiac surgery: A Bayesian network meta‐analysis

L Xu, S Xu, Y Zhang, Y Huang - Brain and Behavior, 2023 - Wiley Online Library
Background Elderly patients are prone to postoperative cognitive dysfunction (POCD). The
comparison of the effects of anesthetic adjuvant drugs on POCD in elderly patients …

Ulinastatin may significantly improve postoperative cognitive function of elderly patients undergoing spinal surgery by reducing the translocation of lipopolysaccharide …

M Zhang, YH Zhang, HQ Fu, QM Zhang… - Frontiers in …, 2018 - frontiersin.org
Background: Studies have shown that perioperative inflammatory response is one of the
important factors that caused postoperative cognitive dysfunction (POCD). Ulinastatin is a …

Multi-organ protection of ulinastatin in traumatic cardiac arrest model

S Liu, J Xu, Y Gao, P Shen, S Xia, Z Li… - World Journal of …, 2018 - Springer
Background Post-cardiac arrest syndrome, which has no specific curative treatment,
contributes to the high mortality rate of victims who suffer traumatic cardiac arrest (TCA) and …

Effect of ulinastatin combined with dexmedetomidine on postoperative cognitive dysfunction in patients who underwent cardiac surgery

M Zhou, Y Lyu, Y Zhu, T Jiang, C Wu, J Yang… - Frontiers in …, 2019 - frontiersin.org
Background: Recent studies have shown that early diagnosis and intervention promote the
patient's good prognosis. For patients who underwent cardiac surgery and require …

Ulinastatin attenuates isoflurane-induced cognitive dysfunction in aged rats by inhibiting neuroinflammation and β-amyloid peptide expression in the brain

M Guo, X Zhu, H Xu, J Li, S Yang, Z Zuo… - Neurological …, 2019 - Taylor & Francis
Objective: Postoperative neurocognitive disease (PNCD) in the aged is a major clinical
problem with unclear mechanisms. This study was designed to explore the mechanisms for …

Postoperative cognitive dysfunction in noncardiac surgery: a review

CM Green, SD Schaffer - Trends in Anaesthesia and Critical Care, 2019 - Elsevier
Abstract Postoperative Cognitive Dysfunction (POCD) following noncardiac surgery is an
underappreciated phenomenon. Researchers consistently find incidence rates around 25 …

Efficacy and Safety of Postoperative Pain Relief by Parecoxib Injection after Laparoscopic Surgeries: A Systematic Review and Meta‐analysis of Randomized …

J Huang, Z Lv, Y Zhang, W Jiang, H Li, M Nie - Pain Practice, 2018 - Wiley Online Library
Objective This study aims to evaluate the efficacy and safety of parecoxib injection in pain
relief after laparoscopic surgeries. Methods A comprehensive literature search based on 4 …